Protein name:
    T-cell-specific surface glycoprotein CD28 ;
    
    Alternative:
    
    TP44 ;
    
    
    CD:
    
    CD28 ;
    
    
 
    Organism:
        
        
        
        
        
        
    
        Human  (Homo sapiens).  
    
 
General Annotation
    Sub Unit:
    Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70.
    
 
    Function:
    Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
    
 
    
        
        Subcellular Location:
        
    
     
     
      Membrane  
      Single-pass type I membrane protein 
     
  
    
 
    
    Protein Attributes:
    
    50:
    MLRLLLALNL |  FPSIQVTGNK |  ILVKQSPMLV |  AYDNAVNLSC |  KYSYNLFSRE |  
    
 
    100:
    FRASLHKGLD |  SAVEVCVVYG |  NYSQQLQVYS |  KTGFNCDGKL |  GNESVTFYLQ |  
    
 
    150:
    NLYVNQTDIY |  FCKIEVMYPP |  PYLDNEKSNG |  TIIHVKGKHL |  CPSPLFPGPS |  
    
 
    200:
    KPFWVLVVVG |  GVLACYSLLV |  TVAFIIFWVR |  SKRSRLLHSD |  YMNMTPRRPG |  
    
 
    220:
    PTRKHYQPYA |  PPRDFAAYRS |  
    
 
      Vaild Sequence:
    
 
Related Databases
Uniprot:
 
 
    
        
        ELISA Kit
         
        
        CLIA Kit
         
        
        Polyclonal Antibody
         
        
        Monoclonal Antibody
         
        
        Protein
         
        
     
FOR
    
        
        Human
         
        
        Rabbit
         
        
        Rat
         
        
        Mouse
         
        
        Bovine
         
        
        Chicken
         
        
     
    
        ELISA Kit for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
    
    
 
    
        Protein for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
    
    
 
    
        Protein for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
    
    
 
    
        Protein for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
    
    
 
    
        Protein for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
    
    
 
    
        Protein for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
    
    
 
    
        Protein for Human T-cell-specific surface glycoprotein CD28
        
     
    
    
    
    
    
    
 
 
 
 
 
 
 
 
    R&D Technical Data
    
    
    
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    Precision
    
    
    
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    Recovery
    
    
    
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    Linearity
    
    
    
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    References
    
    
        
            
        
            
                1.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) 
                    
                    
                 
             
         
            
        
            
                2.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 3);ALTERNATIVE SPLICING 
                    
                    
                 
             
         
            
        
            
                3.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5) 
                    
                    
                 
             
         
            
        
            
                4.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4 AND 6);CHARACTERIZATION (ISOFORM 3) 
                    
                    
                    tissue :
                    
Peripheral blood T-cell .  
             
         
            
        
            
                5.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7) 
                    
                    
                 
             
         
            
        
            
                6.
                
                    
                        
                        
                            Livingston R.J. 
                        ,
                            
Shaffer T. 
                        ,
                            
McFarland I. 
                        ,
                            
Nguyen C.P. 
                        ,
                            
Stanaway I.B. 
                        ,
                            
Rajkumar N. 
                        ,
                            
Johnson E.J. 
                        ,
                            
da Ponte S.H. 
                        ,
                            
Willa H. 
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Ahearn M.O. 
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Bertucci C. 
                        ,
                            
Acklestad J. 
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Carroll A. 
                        ,
                            
Swanson J. 
                        ,
                            
Gildersleeve H.I. 
                        ,
                            
Nickerson D.A. 
                        
                        
                        
                            Submitted (2006-10) to the EMBL/GenBank/DDBJ databases
                        
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [GENOMIC DNA] 
                    
                    
                 
             
         
            
        
            
                7.
                
                    
                        
                            "Complete sequencing and characterization of 21,243 full-length human cDNAs." 
                        
                        
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                        ,
                            
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                        ,
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                            Fujimori Y. 
                        ,
                            Komiyama M. 
                        ,
                            Tashiro H. 
                        ,
                            Tanigami A. 
                        ,
                            Fujiwara T. 
                        ,
                            Ono T. 
                        ,
                            Yamada K. 
                        ,
                            Fujii Y. 
                        ,
                            Ozaki K. 
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                            Hirao M. 
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                            Ohmori Y. 
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                            Kawabata A. 
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                            Hikiji T. 
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                            Kobatake N. 
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                            Inagaki H. 
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                            Ikema Y. 
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                            Okamoto S. 
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                            Okitani R. 
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                            Kawakami T. 
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                            Noguchi S. 
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                            Itoh T. 
                        ,
                            Shigeta K. 
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                            Senba T. 
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                            Matsumura K. 
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                            Nakajima Y. 
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                            Mizuno T. 
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                            Morinaga M. 
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                            Sasaki M. 
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                            Togashi T. 
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                            Oyama M. 
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                            Hata H. 
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                            Watanabe M. 
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                            Komatsu T. 
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                            Mizushima-Sugano J. 
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                            Satoh T. 
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                            Shirai Y. 
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                            Takahashi Y. 
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                            Nakagawa K. 
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                            Okumura K. 
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                            Nagase T. 
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                            Nomura N. 
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                            Kikuchi H. 
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                            Masuho Y. 
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                            Yamashita R. 
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                            Nakai K. 
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                            Isogai T. 
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                            Sugano S. 
                        
                             
                              more...   
                             
                        
                        
                        
                            Nat. Genet.36:40-45(2004)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) 
                    
                    
                    tissue :
                    
Synovium . tissue :
                    
Trachea .  
             
         
            
        
            
                8.
                
                    
                        
                            "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." 
                        
                        
                            Hillier L.W. 
                        ,
                            
Graves T.A. 
                        ,
                            
Fulton R.S. 
                        ,
                            
Fulton L.A. 
                        ,
                            
Pepin K.H. 
                        ,
                            
Minx P. 
                        ,
                            
Wagner-McPherson C. 
                        ,
                            
Layman D. 
                        ,
                            
Wylie K. 
                        ,
                            
Sekhon M. 
                        ,
                            
Becker M.C. 
                        ,
                            
Fewell G.A. 
                        ,
                            
Delehaunty K.D. 
                        ,
                            
Miner T.L. 
                        ,
                            
Nash W.E. 
                        ,
                            
Kremitzki C. 
                        ,
                            
Oddy L. 
                        ,
                            
Du H. 
                        ,
                        
                        
                            Sun H. 
                        ,
                            Bradshaw-Cordum H. 
                        ,
                            Ali J. 
                        ,
                            Carter J. 
                        ,
                            Cordes M. 
                        ,
                            Harris A. 
                        ,
                            Isak A. 
                        ,
                            van Brunt A. 
                        ,
                            Nguyen C. 
                        ,
                            Du F. 
                        ,
                            Courtney L. 
                        ,
                            Kalicki J. 
                        ,
                            Ozersky P. 
                        ,
                            Abbott S. 
                        ,
                            Armstrong J. 
                        ,
                            Belter E.A. 
                        ,
                            Caruso L. 
                        ,
                            Cedroni M. 
                        ,
                            Cotton M. 
                        ,
                            Davidson T. 
                        ,
                            Desai A. 
                        ,
                            Elliott G. 
                        ,
                            Erb T. 
                        ,
                            Fronick C. 
                        ,
                            Gaige T. 
                        ,
                            Haakenson W. 
                        ,
                            Haglund K. 
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                            Holmes A. 
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                            Harkins R. 
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                            Kim K. 
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                            Kruchowski S.S. 
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                            Strong C.M. 
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                            Grewal N. 
                        ,
                            Goyea E. 
                        ,
                            Hou S. 
                        ,
                            Levy A. 
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                            Martinka S. 
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                            Mead K. 
                        ,
                            McLellan M.D. 
                        ,
                            Meyer R. 
                        ,
                            Randall-Maher J. 
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                            Tomlinson C. 
                        ,
                            Dauphin-Kohlberg S. 
                        ,
                            Kozlowicz-Reilly A. 
                        ,
                            Shah N. 
                        ,
                            Swearengen-Shahid S. 
                        ,
                            Snider J. 
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                            Strong J.T. 
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                            Thompson J. 
                        ,
                            Yoakum M. 
                        ,
                            Leonard S. 
                        ,
                            Pearman C. 
                        ,
                            Trani L. 
                        ,
                            Radionenko M. 
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                            Waligorski J.E. 
                        ,
                            Wang C. 
                        ,
                            Rock S.M. 
                        ,
                            Tin-Wollam A.-M. 
                        ,
                            Maupin R. 
                        ,
                            Latreille P. 
                        ,
                            Wendl M.C. 
                        ,
                            Yang S.-P. 
                        ,
                            Pohl C. 
                        ,
                            Wallis J.W. 
                        ,
                            Spieth J. 
                        ,
                            Bieri T.A. 
                        ,
                            Berkowicz N. 
                        ,
                            Nelson J.O. 
                        ,
                            Osborne J. 
                        ,
                            Ding L. 
                        ,
                            Meyer R. 
                        ,
                            Sabo A. 
                        ,
                            Shotland Y. 
                        ,
                            Sinha P. 
                        ,
                            Wohldmann P.E. 
                        ,
                            Cook L.L. 
                        ,
                            Hickenbotham M.T. 
                        ,
                            Eldred J. 
                        ,
                            Williams D. 
                        ,
                            Jones T.A. 
                        ,
                            She X. 
                        ,
                            Ciccarelli F.D. 
                        ,
                            Izaurralde E. 
                        ,
                            Taylor J. 
                        ,
                            Schmutz J. 
                        ,
                            Myers R.M. 
                        ,
                            Cox D.R. 
                        ,
                            Huang X. 
                        ,
                            McPherson J.D. 
                        ,
                            Mardis E.R. 
                        ,
                            Clifton S.W. 
                        ,
                            Warren W.C. 
                        ,
                            Chinwalla A.T. 
                        ,
                            Eddy S.R. 
                        ,
                            Marra M.A. 
                        ,
                            Ovcharenko I. 
                        ,
                            Furey T.S. 
                        ,
                            Miller W. 
                        ,
                            Eichler E.E. 
                        ,
                            Bork P. 
                        ,
                            Suyama M. 
                        ,
                            Torrents D. 
                        ,
                            Waterston R.H. 
                        ,
                            Wilson R.K. 
                        
                             
                              more...   
                             
                        
                        
                        
                            Nature434:724-731(2005)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                 
             
         
            
        
            
                9.
                
                    
                        
                        
                            Mural R.J. 
                        ,
                            
Istrail S. 
                        ,
                            
Sutton G. 
                        ,
                            
Florea L. 
                        ,
                            
Halpern A.L. 
                        ,
                            
Mobarry C.M. 
                        ,
                            
Lippert R. 
                        ,
                            
Walenz B. 
                        ,
                            
Shatkay H. 
                        ,
                            
Dew I. 
                        ,
                            
Miller J.R. 
                        ,
                            
Flanigan M.J. 
                        ,
                            
Edwards N.J. 
                        ,
                            
Bolanos R. 
                        ,
                            
Fasulo D. 
                        ,
                            
Halldorsson B.V. 
                        ,
                            
Hannenhalli S. 
                        ,
                            
Turner R. 
                        ,
                        
                        
                            Yooseph S. 
                        ,
                            Lu F. 
                        ,
                            Nusskern D.R. 
                        ,
                            Shue B.C. 
                        ,
                            Zheng X.H. 
                        ,
                            Zhong F. 
                        ,
                            Delcher A.L. 
                        ,
                            Huson D.H. 
                        ,
                            Kravitz S.A. 
                        ,
                            Mouchard L. 
                        ,
                            Reinert K. 
                        ,
                            Remington K.A. 
                        ,
                            Clark A.G. 
                        ,
                            Waterman M.S. 
                        ,
                            Eichler E.E. 
                        ,
                            Adams M.D. 
                        ,
                            Hunkapiller M.W. 
                        ,
                            Myers E.W. 
                        ,
                            Venter J.C. 
                        
                             
                              more...   
                             
                        
                        
                            Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
                        
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                 
             
         
            
        
            
                10.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] 
                    
                    
                 
             
         
            
        
            
                11.
                
                    
                        
                            "Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches." 
                        
                        
                            Ling V. 
                        ,
                            
Wu P.W. 
                        ,
                            
Finnerty H.F. 
                        ,
                            
Agostino M.J. 
                        ,
                            
Graham J.R. 
                        ,
                            
Chen S. 
                        ,
                            
Jussiff J.M. 
                        ,
                            
Fisk G.J. 
                        ,
                            
Miller C.P. 
                        ,
                            
Collins M. 
                        
                        
                        
                        
                            Genomics78:155-168(2001)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-178 (ISOFORM 1) 
                    
                    
                 
             
         
            
        
            
                12.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-209;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 
                    
                    
                    tissue :
                    
Leukemic T-cell .  
             
         
            
        
            
                13.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71 AND ASN-129 
                    
                    
                    tissue :
                    
Leukemic T-cell .  
             
         
            
        
            
                14.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189 AND TYR-191;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 
                    
                    
                    tissue :
                    
Leukemic T-cell .  
             
         
            
        
            
                15.
                
                    
                        
                            "Crystal structure of a soluble CD28-Fab complex." 
                        
                        
                            Evans E.J. 
                        ,
                            
Esnouf R.M. 
                        ,
                            
Manso-Sancho R. 
                        ,
                            
Gilbert R.J. 
                        ,
                            
James J.R. 
                        ,
                            
Yu C. 
                        ,
                            
Fennelly J.A. 
                        ,
                            
Vowles C. 
                        ,
                            
Hanke T. 
                        ,
                            
Walse B. 
                        ,
                            
Hunig T. 
                        ,
                            
Sorensen P. 
                        ,
                            
Stuart D.I. 
                        ,
                            
Davis S.J. 
                        
                        
                        
                        
                            Nat. Immunol.6:271-279(2005)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 17-152 IN COMPLEX WITH THE FAB FRAGMENT OF A MITOGENIC ANTIBODY;DISULFIDE BONDS;GLYCOSYLATION AT ASN-37 AND ASN-105 
                    
                    
                 
             
         
            
        
            
                16.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 189-196 IN COMPLEX WITH GRB2;INTERACTION WITH GRB2